LOCUS       AF220951               24568 bp    DNA     linear   BCT 12-JUL-2000
DEFINITION  Streptomyces antibioticus 8,8a-deoxyoleandolide synthase 1 (oleAI)
            and 8,8a-deoxyoleandolide synthase 2 (oleAII) genes, complete cds.
ACCESSION   AF220951
VERSION     AF220951.1
KEYWORDS    .
SOURCE      Streptomyces antibioticus
  ORGANISM  Streptomyces antibioticus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
REFERENCE   1  (bases 1 to 24568)
  AUTHORS   Shah,S., Xue,Q., Tang,L., Carney,J.R., Betlach,M. and McDaniel,R.
  TITLE     Cloning, characterization and heterologous expression of a
            polyketide synthase and P-450 oxidase involved in the biosynthesis
            of the antibiotic oleandomycin
  JOURNAL   J. Antibiot. 53 (5), 502-508 (2000)
   PUBMED   10908114
REFERENCE   2  (bases 1 to 24568)
  AUTHORS   Shah,S., Betlach,M. and McDaniel,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JAN-2000) Kosan Biosciences, Inc., 3832 Bay Center
            Place, Hayward, CA 94545, USA
FEATURES             Location/Qualifiers
     source          1..24568
                     /organism="Streptomyces antibioticus"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:1890"
     gene            623..13075
                     /gene="oleAI"
     CDS             623..13075
                     /gene="oleAI"
                     /note="polyketide synthase"
                     /codon_start=1
                     /transl_table=11
                     /product="8,8a-deoxyoleandolide synthase 1"
                     /protein_id="AAF82408.1"
                     /translation="MHVPGEENGHSIAIVGIACRLPGSATPQEFWRLLADSADALDEP
                     PAGRFPTGSLSSPPAPRGGFLDSIDTFDADFFNISPREAGVLDPQQRLALELGWEALE
                     DAGIVPRHLRGTRTSVFMGAMWDDYAHLAHARGEAALTRHSLTGTHRGMIANRLSYAL
                     GLQGPSLTVDTGQSSSLAAVHMACESLARGESDLALVGGVNLVLDPAGTTGVERFGAL
                     SPDGRCYTFDSRANGYARGEGGVVVVLKPTHRALADGDTVYCEILGSALNNDGATEGL
                     TVPSARAQADVLRQAWERARVAPTDVQYVELHGTGTPAGDPVEAEGLGTALGTARPAE
                     APLLVGSVKTNIGHLEGAAGIAGLLKTVLSIKNRHLPASLNFTSPNPRIDLDALRLRV
                     HTAYGPWPSPDRPLVAGVSSFGMGGTNCHVVLSELRNAGGDGAGKGPYTGTEDRLGAT
                     EAEKRPDPATGNGPDPAQDTHRYPPLILSARSDAALRAQAERLRHHLEHSPGQRLRDT
                     AYSLATRRQVFERHAVVTGHDREDLLNGLRDLENGLPAPQVLLGRTPTPEPGGLAFLF
                     SGQGSQQPGMGKRLHQVFPGFRDALDEVCAELDTHLGRLLGPEAGPPLRDVMFAERGT
                     AHSALLSETHYTQAALFALETALFRLLVQWGLKPDHLAGHSVGEIAAAHAAGILDLSD
                     AAELVATRGALMRSLPGGGVMLSVQAPESEVAPLLLGREAHVGLAAVNGPDAVVVSGE
                     RGHVAAIEQILRDRGRKSRYLRVSHAFHSPLMEPVLEEFAEAVAGLTFRAPTTPLVSN
                     LTGAPVDDRTMATPAYWVRHVREAVRFGDGIRALGKLGTGSFLEVGPDGVLTAMARAC
                     VTAAPEPGHRGEQGADADAHTALLLPALRRGRDEARSLTEAVARLHLHGVPMDWTSVL
                     GGDVSRVPLPTYAFQRESHWLPSGEAHPRPADDTESGTGRTEASPPRPHDVLHLVRSH
                     AAAVLGHSRAERIDPDRAFRDLGFDSLTALELRDRLDTALGLRLPSSVLFDHPSPGAL
                     ARFLQGDDTRRPEPGKTNGTRATEPGPDPDDEPIAIVGMACRFPGGVTSPEDLWRLLA
                     AGEDAVSGFPTDRGWNVTDSATRRGGFLYDAGEFDAAFFGISPREALVMDPQQRLLLE
                     TSWEALERAGVSPGSLRGSDTAVYIGATAQDYGPRLHESDDDSGGYVLTGNTASVASG
                     RIAYSLGLEGPAVTVDTACSSSLVALHLAVQALRRGECSLALAGGATVMPSPGMFVEF
                     SRQGGLSEDGRCKAFAATADGTGWAEGVGVLLVERLSDARRLGHRVLAVVRGSAVNQD
                     GASNGLTAPNGPSQQRVIRAALADAGLVPADVDVVEAHGTGTRLGDPIEAQALLATYG
                     QGRAGGRPVVLGSVKSNIGHTQAAAGVAGVMKMVLALGRGVVPKTLHVDEPSAHVDWS
                     AGEVELAVEAVPWSRGGRVRRAGVSSFGISGTNAHVIVEEAPAEPEPEPERGPGSVVG
                     VVPWVVSGRDAGALREQAARLAAHVSGVSAVDVGWSLVATRSVFEHRAVMVGSELDAM
                     AESLAGFAAGGVVPGVVSGVAPAEGRRVVFVFPGQGSQWVGMAAGLLDACPVFAEAVA
                     ECAAVLDPLTGWSLVEVLRGGGEAVLGRVDVVQPALWAVMVSLARTWRYYGVEPAAVV
                     GHSQGEIAAACVAGGLSLADGARVVVLRSRAIARIAGGGGMVSVSLPAGRVRTMLEEF
                     DGRVSVAAVNGPSSTVVSGDVQALDELLAGCEREGVRARRVPVDYASHSAQMDQLRDD
                     LLEALATIVPTSANVPFFSTVTADWLDTTALDAGYWFTNLRETVRFQEAVEGLVAQGM
                     GAFVECSPHPVLVPGITETLDTFDADAVALSSLRRDEGGLDRFLTSLAEAFVQGVPVD
                     WSRAFEGASPRTVDLPTYPFQRQRYWLLDKAAQRERERLEDWRYHVEWRPVTTRPSAR
                     LSGVWAVAIPARLARDSLLVGAIDALERGGARAVPVVVDERDHDRQALVEALRNGLGD
                     DDLAGVLSLLALDEAPHGDHPDVPVGMAASLALVQAMADAAAEVPVWFATRGAVAALP
                     GESPERPRQALLWGLGRVVALEQPQIWGGLVDLPQHLDEDAGRRLVDVVGGLADEDQL
                     AVRASSVLARRLVRTPGHRMSSQAGGREWSPSGTVLVTGGTGALGAHVARWLAGKGAE
                     HLVLISRRGADAAGAAALRDSLTDMGVRVTLAACDAADRHALETLLDSLRTDPAQLTA
                     VIHAAGALDDGMTTVLTPEQMNNALRAKVTATVNLHELTRDLDLSAFVLFSSISATLG
                     IPGQANYAPGNSFLDAFAEWRRAQGLVATSIAWGPWSGGTGMAHEGSVGERLQRHGVL
                     AMEPAAAIAALDHTLASDETAVAVADIDWSRFFLAYTALRARPLIGEIPEARRMLESG
                     SGPGDLEPDRAEPELAVRLAGLTAVEQERLLVQLVREQAAVVLGHSGAEAVAPDRAFK
                     DLGFDSLTSVELRNRLNTATGLRLPVTAVFDYARPAALAGHLRSRLIDDDGDHGALPG
                     VEKHAIDEPIAIVGMACRFPGGIASPEDLWDVLTAGEDVVSGLPQNRGWDLGRLYDPD
                     PDRAGTSYMREGAFLHEAGEFDAAFFGISPREALAMDPQQRLLLETSWEALERAGITP
                     SKLAGSPTGVFFGMSNQDYAAQAGDVPSELEGYLLTGSISSVASGRVAYTFGLEGPAV
                     TVDTACSSSLVALHLAVQGLRRGECSLALVGGVTVMSSPVTLTTFSRQRGLSVDGRCK
                     AFAASADGFGAAEGVGVLLVERLSDARRLGHRVLAVVRGSAVNQDGASNGLAAPNGPS
                     QQRVIRAALADAGLAPADVDVVEAHGTGTRLGDPIEAQALLATYGQGRTSGRPVWLGS
                     VKSNIGHTQAAAGVAGVMKMVLALGRGVVPKTLHVDEPSPHVDWSAGEVELAVEAVPW
                     SRGGRVRRAGVSSFGISGTNAHVIVEEAPAEPSVEEGPGSVVGVVPWVVSGRDAGALR
                     AQAARLAAHVSSTGAGVVDVGWSLVATRSVFEHRAVMVGTDLDSMAGSLAGFAAGGVV
                     PGVVSGVAPAEGRRVVFVFPGQGSQWVGMAAGLLDACPVFAEAVAECAAVLDRLTGWS
                     LVEVLRGGEAVLGRVDVVQPALWAVMVSLARTWRYYGVEPAAVVGHSQGEIAAACVAG
                     GLSLADGARVVVLRSRAIARIAGGGGMVSVGLSAERVRTMLDTYGGRVSVAAVNGPSS
                     TVVSGDAQALDELLAGCEREGVRARRVPVDYASHSAQMDQLRDELLEALADVTPQDSS
                     VPFFSTVTADWLDTTALDAGYWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVLVP
                     GITETLDTFDADAVALSSLRRDEGGLDRFLTSLAEAFVQGVPVDWTHAFEGGRPRFVD
                     LPTYAFQRQRYWLHEEPLQEPVDEAWDAEFWSVVERGDATAVSDLLSTDAEALHTVLP
                     ALSSWRRRRVEHRRLQDWRYRVEWKPFPAALDEVLGGGWLFVVPRGLADDGVVARVVA
                     AVTARGGEVSVVELDPTRPDRRAYAEAVAGRGVSGVVSFLSWDDRRHSEHSVVPAGLA
                     ASLVLAQALVDLGRVGEGPRLWLVTRGAVVAGPSDAGVVIDPVQAQVWGFGRVLGLEH
                     PELWGGLVDLPVGVDEEVCRRFVGVVASAGFEDQVAVRGSGVWVRRLVRAVVDGGGGG
                     WRPRGTVLVTGGLGGLGAHTARWLVGGGADHVVLVSRRGGSAPGAGDLVRELEGLGGA
                     RVSVRACDVADRVALRALLSDLGEPVTAVFHAAGVPQSTPLAEISVQEAADVMAAKVA
                     GAVNLGELVDPCGLEAFVLFSSNAGVWGSGGQAVYAAANAFLDALAVRRRGVGLPATS
                     VAWGMWAGEGMASVGGAARELSRRGVRAMDPERAVAVMADAVGRGEAFVAVADVDWER
                     FVTGFASARPRPLISDLPEVRAVVEGQVQGRGQGLGLVGEEESSGWLKRLSGLSRVRQ
                     EEELVELVRAQAAVVLGHGSAQDVPAERAFKELGFDSLTAVELRNGLAAATGIRLPAT
                     MAFDHPTATAIARFLQSELVGSDDPLTLMRSAIDQLETGLALLESDEEARSEITKRLN
                     ILLPRFGSGGSSRGREAGQDAGEHQDVEDATIDELFEVLDNELGNS"
     misc_feature    650..1906
                     /gene="oleAI"
                     /note="Region: ketoacyl synthase domain KS-Q"
     misc_feature    2309..3415
                     /gene="oleAI"
                     /note="Region: acyltransferase domain AT-L"
     misc_feature    3485..3724
                     /gene="oleAI"
                     /note="Region: acyl carrier protein domain ACP-L"
     misc_feature    3806..5056
                     /gene="oleAI"
                     /note="Region: ketoacyl synthase domain KS1"
     misc_feature    5363..6400
                     /gene="oleAI"
                     /note="Region: acyltransferase domain AT1"
     misc_feature    7109..7669
                     /gene="oleAI"
                     /note="Region: ketoacyl reductase domain KR1"
     misc_feature    7943..8200
                     /gene="oleAI"
                     /note="Region: acyl carrier protein domain ACP1"
     misc_feature    8258..9541
                     /gene="oleAI"
                     /note="Region: ketoacyl synthase domain KS2"
     misc_feature    9848..10882
                     /gene="oleAI"
                     /note="Region: acyltransferase domain AT2"
     misc_feature    11723..12274
                     /gene="oleAI"
                     /note="Region: ketoacyl reductase domain KR2"
     misc_feature    12560..12817
                     /gene="oleAI"
                     /note="Region: acyl carrier protein domain ACP2"
     gene            13118..24568
                     /gene="oleAII"
     CDS             13118..24568
                     /gene="oleAII"
                     /note="polyketide synthase"
                     /codon_start=1
                     /transl_table=11
                     /product="8,8a-deoxyoleandolide synthase 2"
                     /protein_id="AAF82409.1"
                     /translation="MTNDEKIVEYLKRATVDLRKARHRIWELEDEPIAITSMACHFPG
                     GIESPEQLWELLSAGGEVLSEFPDDRGWDLDEIYHPDPEHSGTSYVRHGGFLDHATQF
                     DTDFFGISPREALAMDPQQRLLLETSWQLFERAGVDPHTLKGSRTGVFVGAAHMGYAD
                     RVDTPPAEAEGYLLTGNASAVVSGRISYTFGLEGPAVTVDTACSSSLVALHLAVQALR
                     RGECSLAVVGGVAVMSDPKVFVEFSRQRGLARDGRSKAFAASADGFGFAEGVSLLLLE
                     RLSDARRLGHRVLAVVRGSAVNQDGASNGLAAPNGPSQQRVIRAALADAGLAPADVDV
                     VEAHGTGTRLGDPIEAQALLATYGQGRTSGRPVWLGSVKSNIGHTQAAAGVAGVMKMV
                     LALERGVVPKTLHVDEPSPHVDWSTGAVELLTEERPWEPEAERLRRAGISAFGVSGTN
                     AHVIVEEAPAEPEPEPEPGTRVVAAGDLVVPWVVSGRDAGALRAQAARLAAHVSSTGA
                     GVVDVGWSLVATRSVFEHRAVMVGTDLDSMAGSLAGFAAGGVVPGVVSGVAPAEGRRV
                     VFVFPGQGSQWVGMAAGLLDACPVFAEAVAECAAVLDPLTGWSLVEVLRGGEAVLGRV
                     DVVQPALWAVMVSLARTWRYYGVEPAAVVGHSQGEIAAACVAGGLSLADGARVVVLRS
                     RAIARIAGGGGMVSVSLPAGRVRTMLDTYGGRLSVAAVNGPSSTVVSGDAQALDELLA
                     GCEREGVRARRVPVDYASHSAQMDQLRDELLEALADITPQHSSVPFFSTVTADWLDTT
                     ALDAGYWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVLVPGIEQTLDTVEADAVA
                     LGSLRRDEGGLGRFLTSLAEAFVQGVPVDWSRTFEGASPRTVDLPTYPFQRQRFWLEG
                     SPALSSNGVEGEADVAFWDAVEREDSAVVAEELGIDAKALHMTLPALSSWRRRERQRR
                     KVQRWRYRVEWKRLPNSRAQESLQGGWLLVVPQGRAGDVRVTQSVAEVAAKGGEATVL
                     EVDALHPDRAAYAEALTRWPGVRGVVSFLAWEEQALAEHPVLSAGLAASLALAQALID
                     VGGSGESAPRLWLVTEAAVVIGAADTGAVIDPVHAQLWGFGRVLALEHPELWGGLIDL
                     PAVAGEPGSITDHAHADLLATVLATMVQAAARGEDQVAVRTTGTYVPRLVRSGGSAHS
                     GARRWQPRDTVLVTGGMGPLTAHIVRWLADNGADQVVLLGGQGADGEAEALRAEFDGH
                     TTKIELADVDTEDSDALRSLLDRTTGEHPLRAVIHAPTVVEFASVAESDLVRFARTIS
                     SKIAGVEQLDEVLSGIDTAHDVVFFSSVAGVWGSAGQSAYAAGNAFLDAVAQHRRLRG
                     LPGTSVAWTPWDDDRSLASLGDSYLDRRGLRALSIPGALASLQEVLDQDEVHAVVADV
                     DWERFYAGFSAVRRTSFFDDVHDAHRPALSTAATNDGQARDEDGGTELVRRLRPLTET
                     EQQRELVSLVQSEVAAVLGHSSTDAVQPQRAFREIGFDSLTAVQLRNRLTATTGMRLP
                     TTLVFDYPTTNGLAEYLRSELFGVSGAPADLSVVRNADEEDDPVVIVGMACRFPGGID
                     TPEAFWKLLEAGGDVISELPANRGWDMERLLNPDPEAKGTSATRYGGFLYDAGEFDAA
                     FFGISPREALAMDPQQRLLLETVWELIESAGVAPDSLHRSRTGTFIGSNGQFYAPLLW
                     NSGGDLEGYQGVGNAGSVMSGRVAYSLGLEGPAVTVDTACSSSLVALHLAVQALRRGE
                     CSLAIAGGVTVMSTPDSFVEFSRQQGLSEDGRCKAFASTADGFGLAEGVSALLVERLS
                     DARRLGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALADAGLAPADVDVVEA
                     HGTGTRLGDPIEAQALLATYGQGRAGGRPVVLGSVKSNIGHTQAAAGVAGVMKMVLAL
                     ERGVVPKTLHVDEPSPHVDWSAGEVELAVEAVPWSRGGRVRRAGVSSFGISGTNAHVI
                     VEEAPAEPEPEPGTRVVAAGDLVVPWVVSGRDAGALREQAARLAAHVSSTGAGVVDVG
                     WSLVATRSVFEHRAVMVGSELDSMAESLAGFAAGGVVPGVVSGVAPAEGRRVVFVFPG
                     QGSQWVGMAAGLLDACPVFAEAVAECAAVLDPVTGWSLVEVLRGGGEAVLGRVDVVQP
                     ALWAVMVSLARTWRYYGVEPAAVVGHSQGEIAAACVAGGLSLADGARVVVLRSRAIAR
                     IAGGGGMVSVGLSAERVRTMLDTYGGRVSVAAVNGPSSTVVSGDVQALDELLAGCERE
                     GVRARRVPVDYASHSAQMDQLRDELLEALADITPQHSSVPFFSTVTADWLDTTALDAG
                     YWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVLVPGIEQTLDALDQNAAVLGSLR
                     RDEGGLDRLLTSLAEAFVQGVPVDWTHAFEGMTPRTVDLPTYPFQRQHYWPKPAPAPG
                     ANLGDVASVGLTAAGHPLLGAVVEMPDSDGLVLTGQISLRTHPWLADHEVLGSVLLPG
                     TAFVELAVQAADRAGYDVLDELTLEAPLVLPDRGGIQVRLALGPSEADGRRSLQLHSR
                     PEEAAGFHRWTRHASGFVVPGGTGAARPTEPAGVWPPAGAEPVALASDRYARLVERGY
                     TYGPSFQGLHTAWRHGDDVYAEVALPEGTPADGYALHPALLDAAVQAVGLGSFVEDPG
                     QVYLPFLWSDVTLHATGATSLRVRVSPAGPDTVALALADPAGAPVATVGALRLRTTSA
                     AQLARARGSAEHAMFRVEWVEEGSAADRCRGGAGGTTYEGERAAEAGAAAGTWAVLGP
                     RVPAAVRTMGVDVVTALDTPDHPADPQSLADLAALGDTVPDVVVVTSLLSLASGADSP
                     LGNRPRPTAAEQDTAATVAGVHSALHAALDLVQAWLADERHTASRLVLVTRHAMTVAE
                     SDPEPDLLLAPVWGLVRSAQAENPGRFVLADIDGDEASWDALPRAVASAASEVAIRAG
                     AVYVPRLARATDEGLVVADEAAGPWRLDVTEAGTLANLALVPCPDASRPLGPDEVRIA
                     VRAAGVNFRDVLLALGMYPDEGLMGAEAAGVVTEVGGGVTTLAPGDRVMGLVTGGFGP
                     VAVTHHRMLVRMPRGWSFAEAASVPVAFLTAYYALHDLAGLRGGESVLVHSAAGGVGM
                     AAVQLARHWDAEVFGTASKGKWDVLAAQGLDEEHIGSSRTTEFEQRFRATSGGRGIDV
                     VLNALSGDFVDASARLLREGGRFVEMGKTDIRTDLGVVGADGVPDIRYVAFDLAEAGA
                     ERIGQMLDEIMALFDAGVLRLPPLRAWPVRRAHEALRFVSQARHVGKVVLTVPAALDA
                     EGTVLITGAGTLGALVARHLVTEHDVRRLLLVSRSGVAPDLAAELGALGAEVTVAACD
                     VANRKALKALLEDIPPEHPVTGIVHTAGVLDDGVVSGLTPERVDTVLKPKVDAALTLE
                     SVIGELDLDPALFVIFSSAASMLGGPGQGSYAAANQFLDTLARHRARRGLTSVSLGWG
                     LWHEASGLTGGLADIDRDRMSRAGIAPMPTDEALHLFDRATELGDPVLLPMRLNEAAL
                     EDRAADGTLPPLLSGLVRVRHRPSARAGTATAAPATGPEAFARELAAAPDPRRALRDL
                     VRGHVALVLGHSGPEAIDAEQAFRDIGFDSLTAVELRNRLNAETGLRLPGTLVFDYPN
                     PSALADHLLELLAPATQPTAAPLLAELERVEQLLSAAASPGGPASAVDEETRTLIATR
                     LATLASQWTHLPVGSPGNADNRSGPGESGQAQESGATGEHTAAWTSDDDLFAFLDKRL
                     ET"
     misc_feature    13208..14494
                     /gene="oleAII"
                     /note="Region: ketoacyl synthase domain KS3"
     misc_feature    14816..15850
                     /gene="oleAII"
                     /note="Region: acyltransferase domain AT3"
     misc_feature    16748..17302
                     /gene="oleAII"
                     /note="Region: ketoacyl reductase domain KR3"
     misc_feature    17579..17836
                     /gene="oleAII"
                     /note="Region: acyl carrier protein domain ACP3"
     misc_feature    17897..19180
                     /gene="oleAII"
                     /note="Region: ketoacyl synthase domain KS4"
     misc_feature    19496..20533
                     /gene="oleAII"
                     /note="Region: acyltransferase domain AT4"
     misc_feature    20570..21109
                     /gene="oleAII"
                     /note="Region: dehydratase domain DH4"
     misc_feature    22280..23152
                     /gene="oleAII"
                     /note="Region: enoyl reductase domain ER4"
     misc_feature    23165..23713
                     /gene="oleAII"
                     /note="Region: ketoacyl reductase domain KR4"
     misc_feature    23996..24247
                     /gene="oleAII"
                     /note="Region: acyl carrier protein domain ACP4"
ORIGIN      
        1 caaatcctcc gcgccctcgt gctgcgaggc gcatgaaatg ggcggttgtc gcgaccacag
       61 tgcaccgtca ccgaagccgg agcaatgccc gtgaataagg tcgcgccctt ccgtggatga
      121 tctccgcacg agatcatgcc cagctcaagt gatggtcatg cacgtaccaa gaaggggctt
      181 gcctgggggg cgtgagctga tctagcgttg ccgcacgacg acgagtcgtg agcgaggcga
      241 acgctctgcc gctcaggggg tgaacagacg gcagcccgga cgttcgacga gggtcaagcg
      301 gaacgcaggc gacaggacgc ggccaccctc cgaggcaccc gtgccgacca tcctcgcagg
      361 tccttcgcca tgcccgtcgc aactctccga tcgctgccgc cgatggcgac agcccggcac
      421 cgaggcccct ggaccaggag gcgaagcgag ggccggccgc gatgcacgaa tcggacccag
      481 gcgaacaccg gcacatccac cccggcgcgt gcggtacggg ccgcgcccga tgacgggcga
      541 acgacgaccg aaaagcagac cccttgattc gcttccatgg ttgtggcagc cgcggggagc
      601 gtcggcagag aggtgggaaa ccatgcatgt ccccggcgag gaaaacgggc attccattgc
      661 cattgtcgga attgcgtgcc gactgccggg ctctgccacc ccccaggagt tctggagact
      721 cctggccgac tccgcagacg cattggacga gccccccgcc ggccgtttcc cgaccggctc
      781 attatcctcg ccccccgctc cgcgcggcgg attcctcgac agcatcgaca ctttcgacgc
      841 ggatttcttc aacatctcgc ccagagaagc cggtgtcctc gacccccagc aacgcctcgc
      901 gctggaactc ggctgggagg cgctggaaga cgccggaatc gtcccgcgac acctcagggg
      961 aacccgcacc tcggtcttca tgggcgccat gtgggacgac tacgcgcacc tggcgcacgc
     1021 acggggagaa gccgccctca cccggcattc cctgacggga acgcaccgcg gcatgatcgc
     1081 caaccggctc tcctacgccc tgggcctcca aggccccagc ctcaccgtcg acaccggaca
     1141 atcctcctcc ctcgccgccg tgcacatggc ctgcgagagc ctggcccgcg gcgaatccga
     1201 cctcgccctc gtcggcggcg tcaacctcgt cctcgatccg gccggcacga ccggcgtcga
     1261 gaggttcgga gcactctcac cggacggcag gtgctacacc ttcgactccc gggcgaacgg
     1321 ctacgcccga ggagagggcg gcgtcgtagt cgtcctcaag cccacccacc gcgcgctcgc
     1381 ggacggtgac accgtctact gcgagatcct gggcagcgcc ctcaacaacg acggcgccac
     1441 ggaaggcctc accgtcccca gcgcccgcgc ccaggcggac gtcctgcgac aggcatggga
     1501 acgggcacgc gtggccccga cggacgtcca gtacgtggaa ctgcacggaa ccggcacacc
     1561 ggccggcgac cccgtcgagg ccgagggcct cggcaccgcg ctcggcaccg cacgcccggc
     1621 cgaggcgccg ctcctggtcg gctcggtcaa gacgaacatc ggtcacctcg aaggcgcggc
     1681 aggcatcgcg ggcctcctga agacggtcct gagcatcaag aaccggcacc tcccggcaag
     1741 cctgaacttc acctcgccca acccccgcat cgacctcgac gccctgcgcc tgcgcgtcca
     1801 caccgcgtac ggcccctggc cgagccccga ccggccgctg gtggcgggcg tctcctcctt
     1861 cggcatgggc gggacgaact gccacgtcgt cctgtccgag ttacggaacg cgggaggcga
     1921 cggcgccgga aaagggccgt acaccggcac ggaagaccgg ctcggcgcca cggaggcgga
     1981 gaagaggccg gacccggcaa ccggaaacgg tcctgatccc gcccaggaca cccaccgcta
     2041 cccgccgctg atcctgtccg cccgcagcga cgcggccctg cgcgcacagg cggaacggct
     2101 ccgccaccac ctggaacaca gccccggaca gcgcctgcgg gacaccgcct acagcctggc
     2161 gacccgccgc caggtcttcg agcggcacgc ggtggtcacc ggacacgacc gcgaggacct
     2221 gctcaacggc ctgcgtgacc tggagaacgg cctcccggcc ccccaggtcc tgctcggccg
     2281 cacgcccacc cccgaaccgg gcggcctcgc cttcctcttc tccgggcagg gcagccagca
     2341 gcccggcatg ggcaagcgac tccaccaggt gttccccggc ttccgggacg ccctggacga
     2401 ggtctgcgcc gaactcgaca cccacctcgg ccgactcctc ggccccgagg ccggcccgcc
     2461 cctgcgcgac gtgatgttcg ccgagcgggg cacggcgcac agcgccctgc tctccgagac
     2521 ccactacacc caggccgccc tcttcgccct ggaaaccgcc ctcttccgcc tcctggtcca
     2581 gtggggcctg aaacccgacc acctcgcagg ccactccgtc ggcgagatcg cggccgccca
     2641 cgcagcaggc atcctcgacc tgtccgacgc ggccgaactc gtggccaccc gcggcgcgtt
     2701 gatgcgttcc ctgcccggcg gcggcgtcat gctctcggtc caggcacccg agtccgaggt
     2761 cgcacccctg ctgctcggcc gtgaggccca cgtcggcctg gccgccgtga acggccccga
     2821 cgcggtggtc gtgtccggcg agcgcggcca cgtcgccgcc atcgaacaga tcctccggga
     2881 caggggccgc aaaagccggt acctgcgcgt cagccacgcc ttccactccc cgctcatgga
     2941 accggtgctg gaggagttcg ccgaagccgt cgccggcctg accttccggg caccgaccac
     3001 acccctcgtc tccaacctca ccggcgcacc agtcgacgac cggaccatgg ccacgcccgc
     3061 ctactgggtc cggcacgtcc gggaagcggt ccgcttcggc gacggcatcc gggcactcgg
     3121 gaaactgggc accggcagct tcctggaagt cgggccggac ggcgtcctca ccgccatggc
     3181 gcgcgcatgc gtcaccgccg ccccggagcc cggccaccgc ggcgaacagg gcgccgatgc
     3241 cgacgcccac accgcgttgc tgctgcccgc cctgcgccga ggacgggacg aggcgcgatc
     3301 gctcaccgag gccgtggcac ggctccacct gcacggcgtg ccgatggact ggacctccgt
     3361 cctcggcggc gacgtgagcc gggtccccct cccgacgtac gccttccaac gcgaatccca
     3421 ctggctgccg tccggagagg ctcacccgcg accggcggac gacaccgaat ccggcacggg
     3481 acggaccgag gcgtccccgc cgcggccgca cgacgtcctg cacctcgtgc gctcccacgc
     3541 ggcggctgtg ctcggacatt cccgggccga gcggatcgac cccgaccgcg cgttccgcga
     3601 cctcggcttc gactcgctga cggcgctgga actgcgggac cggctcgaca ccgcactcgg
     3661 cctccgcctg cccagcagcg tgctcttcga ccacccgagc cccggcgcac tggcacgctt
     3721 cctccagggc gacgacacga ggcgccccga accagggaag acgaacggca cgcgcgccac
     3781 ggagccaggc ccggacccgg acgacgagcc gatcgccatc gtcggcatgg cgtgccgctt
     3841 cccgggtggc gtgacctctc cggaggacct gtggcgcctg ctcgccgcag gcgaggacgc
     3901 ggtgtccggc ttccccacgg accggggctg gaacgtcact gactccgcca cgcgccgcgg
     3961 aggcttcctg tacgacgccg gcgagttcga tgccgccttc ttcggtatct cgccgcgtga
     4021 ggcgttggtg atggacccgc agcagcggtt gctgctggag acgtcctggg aggccctcga
     4081 acgcgcgggc gtgagccccg gcagtctgcg cggcagcgac acggccgtgt acatcggagc
     4141 cacagcgcag gactacggcc cccgactgca cgagtcggac gacgactcgg gcggctacgt
     4201 cctgaccggc aataccgcca gcgtggcctc cggccgcatc gcctactccc tcggtctgga
     4261 ggggcctgcg gtcacggtgg acacggcgtg ttcgtcgtcg ctggtggcac tgcacctggc
     4321 ggtgcaggcg ctgcgccgtg gcgagtgctc actggcattg gccggcggag ccacggtgat
     4381 gccttcgccc ggcatgttcg tggagttctc acggcaaggg ggcctctccg aggacggccg
     4441 ctgcaaggcg ttcgccgcga cggcggacgg caccggctgg gccgagggtg tgggtgtgtt
     4501 gttggtggag cggttgtcgg atgcgcggcg gttgggtcat cgggtgttgg cggtggtgcg
     4561 ggggagtgcg gtcaatcagg atggtgcgtc gaatgggttg acggcgccga atggtccgtc
     4621 gcagcagcgg gtgatccgtg cggcgttggc tgacgcgggt ctggttcctg ctgatgtgga
     4681 tgtggtggag gcgcatggta cggggacgcg gttgggtgat ccgatcgagg ctcaggcgtt
     4741 gttggcgacg tatgggcagg ggcgtgcggg tgggcgtccg gtggtgttgg ggtcggtgaa
     4801 gtcgaacatc ggtcatacgc aggcggcggc tggtgtggct ggtgtgatga agatggtgct
     4861 ggcgctgggg cggggtgtgg tgccgaagac gttgcatgtg gatgagccgt ctgcgcatgt
     4921 ggactggtcg gctggtgagg tggagttggc ggttgaggcg gtgccgtggt cgcggggtgg
     4981 gcgggtgcgg cgggctggtg tgtcgtcgtt cgggatcagt ggcacgaatg cgcatgtgat
     5041 cgtggaggag gcgcctgcgg agccggagcc ggagccggag cggggtccgg gctctgttgt
     5101 gggtgtggtg ccgtgggtgg tgtccgggcg ggatgcgggg gcgttgcgtg agcaggcggc
     5161 acgcttggct gcgcacgtgt cgggtgtaag tgcggtcgat gtgggctggt cgttggtggc
     5221 cacgaggtcg gtgttcgagc accgggcggt gatggtcggc agtgaactcg atgccatggc
     5281 ggagtcgttg gccggcttcg ctgcgggtgg ggttgtgccg ggggtggtgt cgggtgtggc
     5341 tccggctgag ggtcgtcgtg tggtgttcgt ctttcctggt cagggttcgc agtgggtggg
     5401 gatggcggct gggttgctgg atgcgtgccc ggtgttcgcg gaggcggtgg cggagtgcgc
     5461 tgcggtgctg gacccgttga ccggttggtc gctggtcgag gtgttgcgcg gtggtggtga
     5521 ggctgttctt gggcgggttg atgtggtgca gccggcgttg tgggcggtga tggtgtcact
     5581 ggcccggacc tggcggtatt acggtgtgga gcctgctgcg gttgtggggc attcgcaggg
     5641 tgagattgct gcggcttgtg tggctggggg gttgagtctg gccgatggtg cgcgggtggt
     5701 ggtgttgcgg agccgggcga tcgcccggat cgctggtggg ggcggcatgg tctccgtcag
     5761 cctgccggcc ggccgtgtcc gcaccatgct ggaggagttc gacggcaggg tttccgttgc
     5821 ggcggtcaac ggtccgtcct cgaccgtggt gtcgggtgac gtccaggccc tggatgagtt
     5881 gttggccggt tgtgagcggg agggtgtccg ggctcgtcgt gtcccggtgg actatgcctc
     5941 ccactccgcg cagatggacc agttacgcga tgatctgctg gaagcgctgg cgacgatcgt
     6001 ccctacatcg gcgaacgtac cgttcttctc gacggtgacg gcggactggc tggacacgac
     6061 cgctctggat gcggggtact ggttcacgaa tctgcgggag acggtccggt tccaagaagc
     6121 cgtcgaaggg ctcgtggctc aggggatggg cgcgttcgtc gagtgcagcc cgcaccccgt
     6181 cctcgtcccg ggcatcacag aaacactcga caccttcgac gccgacgctg tcgcactgtc
     6241 gtcgctgcgg cgtgacgaag gcggcctgga tcggttcctc acgtccctcg cggaagcctt
     6301 cgtccagggc gtcccggtcg actggtcccg cgccttcgag ggtgcgagcc cccgcaccgt
     6361 cgacctgccc acctacccct tccaacggca acgctactgg ctgctcgaca aggcggcgca
     6421 acgggaacgc gagcggctgg aggactggcg ctaccacgtc gagtggcgcc ccgtcacgac
     6481 acgaccttcc gcacggctgt ccggtgtctg ggccgtggcg attccggcac gtctggcccg
     6541 tgactcactg ttggtcggcg ccatcgacgc actggagcga ggcggcgccc gtgccgtgcc
     6601 cgtggtggtc gatgagcggg accacgaccg gcaagcgctg gtcgaggctc tgcggaacgg
     6661 gctgggcgac gacgacctcg ccggtgtgct ctcccttttg gccctcgacg aagccccgca
     6721 cggtgaccac cccgacgtgc ccgtcggcat ggccgcttcg ctggcgctcg tgcaggcgat
     6781 ggccgacgcc gcggccgagg tgcccgtatg gttcgcgacc cgaggcgccg tagcggcact
     6841 gcccggtgag tcaccggagc gacccaggca ggcgctgctc tggggactgg gacgggtcgt
     6901 cgccctggaa cagccgcaga tatggggcgg gttggtcgac ctcccgcaac acctggacga
     6961 ggacgcgggc cgacggctgg tcgatgtcgt gggcggcctg gcggacgagg accagcttgc
     7021 cgtacgggcc tcctccgtcc tcgcccgacg cctcgttcgt acgccgggtc accgtatgtc
     7081 gagccaggcg ggcgggcgcg agtggtcgcc cagcggcacg gtcctggtga ccggaggcac
     7141 cggggcgctg ggcgcgcacg tcgcccgctg gctggccggc aagggcgccg agcacctggt
     7201 actcatcagc cgtcgcggag cggacgcagc cggggccgct gcccttcggg acagcctcac
     7261 ggacatgggt gtccgggtga ccctggccgc gtgcgatgca gcggaccggc acgcactgga
     7321 gacgctcctc gactcgctgc gcacggatcc ggcgcagctg acggccgtca tccacgccgc
     7381 gggtgctctg gacgacggca tgacgacggt gctcacaccg gagcagatga acaacgccct
     7441 gcgagcgaaa gtcacggcca ccgtcaacct gcacgaactg acccgggacc tcgacctctc
     7501 ggccttcgta ctgttctcgt ccatctccgc caccctggga atccccgggc aggccaacta
     7561 cgcgccggga aactcgttct tggacgcctt cgcggaatgg cgcagggctc aggggctcgt
     7621 ggcgacctcc atcgcctggg gaccgtggtc cggcggcacc ggcatggcac atgaagggtc
     7681 ggtgggcgaa cggctccagc ggcacggtgt actcgccatg gaacccgcgg cggccatcgc
     7741 tgcgctcgac cacacgctgg cgagcgacga aaccgcagtg gccgtggccg acatcgactg
     7801 gagccggttc ttcctggcgt acacagcact gcgggcacgg cccttgatcg gagagatacc
     7861 cgaggcacgc cgcatgctgg agtccggctc aggccccggc gacctcgagc cggaccgtgc
     7921 cgaacccgag cttgccgtgc gtctcgcggg cctcaccgcg gtcgagcagg aacgtcttct
     7981 ggtgcagctc gtgagggagc aggccgccgt cgtcctcgga cattccggcg ccgaggcggt
     8041 ggctccggac cgagcgttca aggatctcgg attcgactcg ctgacctcgg tcgaactgcg
     8101 caaccggctg aacaccgcca ccggcctcag actgcccgtg acggccgtct tcgactacgc
     8161 gaggcccgcg gcgctggccg gccatctgcg ctccaggctg atcgacgacg atggtgacca
     8221 cggtgccttg cccggcgtgg agaagcacgc gatcgacgag ccgatcgcga tcgtgggaat
     8281 ggcatgccgc ttcccgggag gcatcgcttc cccggaggat ctgtgggacg tgctcaccgc
     8341 tggtgaggac gttgtctccg gactgccgca gaaccgcggg tgggacttgg ggcgcctgta
     8401 cgatcccgat ccggaccggg ccggtacgtc atacatgcgt gagggtgctt tcctgcacga
     8461 ggcgggggag ttcgacgcgg ccttcttcgg tatctcgccg cgtgaggcgt tggcgatgga
     8521 cccgcagcag cggttgctgc tggagacgtc ctgggaggcc ctcgaacggg ccggcatcac
     8581 tccttccaag ctggcgggca gtccgaccgg tgtgttcttc ggcatgtcga accaggacta
     8641 cgccgcccag gcgggcgacg tgccgtccga gctggagggc tacctgctca ccggctccat
     8701 ctccagcgtc gcttcggggc gtgttgctta cacgttcggt cttgaggggc ctgcggtgac
     8761 ggtggatacg gcgtgttcgt cgtcgttggt ggcgttgcat ctggcggtgc aggggttgcg
     8821 gcggggtgag tgttcgcttg cgttggtggg tggggtgacg gtgatgtcgt cgccggtgac
     8881 gttgacgacg ttcagtcggc agcggggttt gtcggtggat gggcggtgca aggcgttcgc
     8941 ggcttcggcg gatggttttg gtgctgccga gggtgtgggt gtgttgttgg tggagcggtt
     9001 gtcggatgcg cggcggttgg gtcatcgggt gttggcggtg gtgcggggga gtgcggtcaa
     9061 tcaggatggt gcgtccaatg gtctggcggc gccgaatggt ccgtcgcagc agcgggtgat
     9121 ccgtgcggcg ttggctgacg cgggtctggc tcctgccgat gtggatgtgg tggaggcgca
     9181 tggcacgggg acgcggttgg gtgatccgat cgaggctcag gcgttgctgg cgacgtatgg
     9241 gcagggtcgt accagtgggc gtccggtgtg gctggggtcg gtgaagtcga acatcgggca
     9301 tacgcaggcg gcggccggtg tggctggtgt gatgaagatg gtgctggcgt tgggtcgggg
     9361 tgtggtgccg aagacgttgc atgtggatga gccgtcaccg catgtggact ggtcggctgg
     9421 tgaggtggag ttggcggttg aggcggtgcc gtggtcgcgg ggtgggcggg tgcggcgggc
     9481 tggtgtgtcg tcgttcggga tcagcggcac gaatgcgcat gtgatcgtgg aggaggcgcc
     9541 tgcggagcct tcggtggagg agggtccggg ctccgttgtg ggtgtggtgc cgtgggtggt
     9601 gtccgggcgg gatgcggggg cgttgcgtgc acaggcggca cgcttggctg cgcacgtgtc
     9661 gagcacgggt gcgggtgtgg ttgatgtggg ctggtcgttg gtggccacga ggtcggtgtt
     9721 cgagcaccgg gcggtaatgg tcggcactga tcttgattcc atggcggggt cgttggccgg
     9781 cttcgctgcg ggtggtgttg tgccgggggt ggtgtcgggt gtggctccgg ctgagggccg
     9841 tcgtgtggtg ttcgtctttc ctggtcaggg ttcgcagtgg gtggggatgg cggctgggtt
     9901 gctggatgcg tgtccggtgt tcgcggaggc ggtggcggag tgtgccgcgg tgctggaccg
     9961 gttgaccggt tggtcgctgg tcgaggtgtt gcgtggtggt gaggctgttc ttgggcgggt
    10021 tgatgtggtg cagccggcgt tgtgggcggt gatggtgtca ctggctcgga cctggcggta
    10081 ttacggtgtg gagcctgctg cggttgtggg gcattcgcag ggtgagattg ctgcggcttg
    10141 tgtggctggg gggttgagtc tggccgatgg tgcgcgggtg gtggtgttgc ggagtcgggc
    10201 gatcgcccgg atcgctggtg ggggcggcat ggtctcggtc ggtctttcag ctgagcgtgt
    10261 ccgcaccatg ctcgacacct acggcggcag ggtttccgtc gcggcggtca atggcccgtc
    10321 ctcgaccgtg gtgtccggtg acgcccaggc cctggatgag ttgttggccg gttgtgagcg
    10381 ggagggtgtc cgggctcgtc gtgtcccggt ggactatgcc tcccactccg cgcagatgga
    10441 ccagttacgc gatgagttgc tggaggcgct ggcggacgtc actccgcagg actccagtgt
    10501 tccgtttttc tcgacggtga cggcggactg gctggacacg accgctctgg atgcggggta
    10561 ctggttcacg aatctgcggg agacggtccg gttccaggaa gccgttgaag ggcttgtggc
    10621 tcaggggatg ggcgcgttcg tcgagtgcag cccgcaccct gtcctcgtcc cgggcatcac
    10681 agaaacactc gacaccttcg acgccgacgc tgtcgcactg tcgtcgctgc ggcgtgacga
    10741 aggcggcctg gatcggttcc tcacgtccct cgcggaagcc ttcgtccaag gcgttcccgt
    10801 cgactggacc catgccttcg agggtggacg cccgcgcttc gtcgacctgc ccacctatgc
    10861 cttccagcga cagcgctact ggctgcacga agagccgctg caagagccgg tcgatgaggc
    10921 gtgggatgcc gagttctggt ctgtggtcga acgcggcgat gccacagccg tgtccgactt
    10981 gctgagcacg gacgccgagg ctttgcacac ggtgttgccg gctttgtcgt cgtggcggcg
    11041 gcgtcgggtg gagcatcgac ggcttcagga ctggcgttac cgggtggagt ggaagccttt
    11101 cccggccgcg cttgatgagg tgctcggtgg tggctggttg ttcgtggtgc cgcggggctt
    11161 ggcggatgat ggtgtggttg cgcgggtggt ggctgccgtc acggcgcggg gtggcgaggt
    11221 cagtgtcgtg gagctcgatc cgacccgtcc tgaccgccgg gcttatgcgg aggctgtcgc
    11281 gggccgtggt gtgagcgggg tcgtgtcgtt cttgtcctgg gatgatcggc ggcactcgga
    11341 gcattctgtt gttcccgccg gtcttgccgc gtcgctggtg ttggcgcagg cgttggttga
    11401 tcttggccgg gttggtgagg ggccgcggtt gtggctggtg acgcggggtg cggtggttgc
    11461 tggtccttcg gatgccggtg tggtgattga tccggtgcag gcgcaggtgt ggggtttcgg
    11521 gcgtgttctg ggtctggagc atcccgagtt gtggggtggg ctggtggacc tgccggtggg
    11581 ggttgatgag gaggtgtgcc ggcggttcgt gggtgttgtg gcgtcggctg gttttgagga
    11641 tcaggtggcg gtgcgtggtt cgggtgtgtg ggtgcgtcgt ctggtgcgtg ctgtggtgga
    11701 tggtggtggg ggtggttggc ggccgcgtgg gacggtgttg gtcacgggtg gtcttggtgg
    11761 tttgggtgcg catacggccc ggtggttggt gggtggtggg gcggatcatg tggttcttgt
    11821 gagccgtcgt ggtggcagtg cgcctggtgc tggggatctg gtgcgggagc tggaggggtt
    11881 gggcggggct cgggtgtcgg tgcgggcctg tgatgtggct gatcgtgtgg cgttgcgggc
    11941 gttgttgtcg gatctgggtg agccggtgac ggcggtgttc catgcggctg gtgttcctca
    12001 gtcgacgcct ttggcggaga tctctgtcca ggaggcggct gatgtgatgg cggccaaggt
    12061 ggcgggtgcg gtgaatctgg gtgagttggt ggatccctgt ggtctggagg cgtttgtgtt
    12121 gttctcctcc aatgccggtg tgtggggcag tggggggcag gcggtgtatg cggcggcgaa
    12181 tgcgtttctt gatgcgttgg cggtgcgtcg tcggggtgtt ggtctgccgg ccacgagtgt
    12241 ggcgtggggg atgtgggctg gtgaggggat ggcgtcggtg ggtggtgcgg cgcgggagtt
    12301 gtcccgtcgg ggggtgcggg cgatggatcc cgagcgtgct gtggcggtga tggctgatgc
    12361 ggtgggtcgt ggtgaggcgt tcgtcgcggt cgctgatgtg gactgggaac gtttcgtcac
    12421 cggtttcgct tctgcccgtc cccgtccgtt gatcagtgac ctgccggagg tgcgtgctgt
    12481 tgtggagggc caggtccagg gccggggcca ggggttgggc ttggtcggtg aggaggagtc
    12541 gtcggggtgg ttgaagcggt tgtcggggtt gtctcgtgtg cggcaggagg aggagttggt
    12601 ggagttggtc cgtgctcagg ctgccgttgt tctcgggcat ggttccgcgc aggacgtccc
    12661 ggctgagcgg gcgttcaagg agttgggttt tgattccctc actgctgtcg agctacgcaa
    12721 cgggctggcc gcggccaccg ggatccggct gccggccacc atggcattcg atcatcccac
    12781 cgccaccgcc atcgcacgct tcctgcaatc cgaactcgtg ggaagtgacg acccgctgac
    12841 gctcatgcgg tcggcgatcg accagttgga gaccggtctg gctctgctgg aatcggacga
    12901 agaagctcgc tcggaaatca cgaagcgatt gaacattctt ctgccccgct tcggaagcgg
    12961 aggcagttcg agaggcaggg aagcaggaca agacgcaggc gaacatcagg atgtcgagga
    13021 cgccaccatc gatgagctat tcgaggtgct cgacaacgaa ctcggcaatt cctgaaaacc
    13081 tgtccgactg ctaccgcgac cttgaccgga gaacgctgtg acgaacgacg aaaagatcgt
    13141 cgagtatctc aagcgcgcga ccgtggacct gcgcaaggcc cggcaccgca tctgggagct
    13201 ggaggacgag cccatcgcga tcacgtcgat ggcctgccac ttcccgggcg ggatcgagag
    13261 tccggagcag ctgtgggaac tcctgtccgc cggaggcgag gtgctttccg agttccccga
    13321 cgaccgcggc tgggacctgg acgagatcta ccatcctgac ccggaacaca gtgggacgag
    13381 ctacgtccgt cacggcggtt tcctggatca tgcgacgcag ttcgacacgg acttcttcgg
    13441 tatctcgccg cgtgaggcgt tggcgatgga cccgcagcag cggttgctgc tggagacgtc
    13501 ctggcagctt ttcgagcgcg caggagtcga tccccatacg ctgaagggaa gccggaccgg
    13561 agtattcgtc ggcgccgcac acatgggtta tgcggacagg gtggacactc cgccggcgga
    13621 ggccgagggc tacctgctga cagggaacgc ctcggccgtt gtctccgggc gtatttccta
    13681 caccttcggc cttgaggggc ctgcggtgac ggtggacacg gcgtgctcgt cgtcgctggt
    13741 ggcgctgcac ctggcggtgc aggcgctgcg ccgtggcgag tgctcgctgg cggtcgtcgg
    13801 tggtgtggcc gtcatgtcgg acccgaaggt cttcgtcgag ttcagccggc agcgcggact
    13861 ggccagggac ggccggtcca aggcttttgc ggcgtcagcg gatggtttcg gcttcgccga
    13921 gggagtttcg ctgctcttgc tggagcggtt gtcggatgcg cggcggttgg gtcatcgggt
    13981 gttggcggtg gtgcggggga gtgcggtcaa tcaggatggt gcgtccaatg gtctggcggc
    14041 gccgaatggt ccgtcgcagc agcgggtgat tcgtgcggcg ttggctgacg cgggtctggc
    14101 tcctgccgat gtggatgtgg tggaggcgca tggtacgggg acgcggttgg gtgatccgat
    14161 cgaggctcag gcgttgctgg cgacgtatgg gcaggggcgt accagtgggc gtccggtgtg
    14221 gctggggtcg gtgaagtcga acatcggtca tacgcaggcg gcggccggtg tggctggtgt
    14281 gatgaagatg gtgctggctc tggagcgggg tgtggtgccg aagacgttgc acgtggatga
    14341 gccgtctccg catgtggact ggtcgaccgg tgcggtggag ttgctgactg aagagcggcc
    14401 gtgggagccg gaggctgagc gtcttcgtcg ggcaggcatt tccgccttcg gtgtcagtgg
    14461 cacgaatgcg catgtgatcg tggaggaggc acctgcggaa ccggaaccgg agccggagcc
    14521 gggaactcgt gtggttgctg ccggtgatct ggtggtgccg tgggtggtgt ccgggcggga
    14581 tgcgggggcg ttgcgtgcac aggcggcacg cttggctgcg catgtgtcga gcacgggtgc
    14641 gggtgtggtt gatgtgggct ggtcgttggt ggccacgagg tcggtgttcg agcaccgggc
    14701 ggtgatggtc ggcactgatc ttgattccat ggcggggtcg ttggccgggt ttgctgcggg
    14761 tggggttgtg ccgggggtgg tgtcgggtgt ggctccggct gagggtcgtc gtgtggtgtt
    14821 cgtctttcct ggtcagggtt cgcagtgggt ggggatggcg gctgggttgc tggatgcgtg
    14881 tccggtgttc gcggaggcgg tggcggagtg tgccgcggtg ctggacccgt tgaccggttg
    14941 gtcgctggtc gaggtgttgc gcggtggtga ggctgttctt gggcgggttg atgtggtgca
    15001 gccggcgttg tgggcggtga tggtgtcact ggctcggacc tggcggtatt acggtgtgga
    15061 gcctgctgcg gttgtggggc attcgcaggg tgagattgct gcggcttgtg tggctggggg
    15121 gttgagtctg gccgatggtg cgcgggtggt ggtgttgcgg agccgggcga tcgcccggat
    15181 cgccggtggg ggcggcatgg tctccgtcag tctcccggcc ggccgtgtcc gcaccatgct
    15241 cgacacctac ggcggccggt tgtcggtggc tgcggtcaac ggcccgtcct cgaccgtggt
    15301 gtccggtgac gcccaggccc tggatgagtt gttggccggc tgtgagcggg agggggtccg
    15361 ggctcgtcgt gtcccggtgg actatgcctc ccactccgcg cagatggacc agttacgcga
    15421 tgagctgctg gaagcgctgg cggacatcac tccgcaacac tccagcgttc cgttcttctc
    15481 gacggtgacg gcggactggc tggacacgac cgctctggat gcggggtact ggttcacgaa
    15541 tctgcgggag acggtccggt tccaggaagc cgtcgaaggg cttgtggctc aggggatggg
    15601 cgcgttcgtc gagtgcagcc cacaccccgt cctcgtcccc ggtatcgagc agaccctcga
    15661 caccgtggaa gccgatgctg tggcgctggg ttcgctacgg cgtgatgagg gcggcctggg
    15721 acggttcctc acgtccctcg cggaagcctt cgtccagggc gtcccggtcg actggtcccg
    15781 caccttcgag ggtgcgagcc cccgcaccgt cgacctgccc acctatccct tccaacggca
    15841 acgtttctgg ttggagggat ccccggcgtt gtcttcgaac ggcgtcgagg gtgaggcgga
    15901 cgtcgcgttc tgggatgcgg tcgagcgcga ggactcggcg gttgtagccg aggagttggg
    15961 gatcgacgcc aaggctctgc acatgacatt gccggccttg tcgtcgtggc ggcggcgtga
    16021 gcggcagcgt cggaaggtgc agcgctggcg ttaccgggtg gagtggaagc gtctcccgaa
    16081 ttcgcgggca caggagtcgc tgcagggcgg ctggttgctc gtcgtcccgc agggccgtgc
    16141 cggcgatgtc cgcgtcactc agtcggtggc ggaggtggcg gccaagggtg gtgaagccac
    16201 ggtcctggag gtcgacgccc tgcatcccga ccgcgcagca tacgccgagg ccctcacccg
    16261 gtggccgggt gtgcggggtg tggtgtcgtt cctggcgtgg gaggagcagg cccttgccga
    16321 acaccccgtt ctgtctgcgg gtctggcggc atcgctggcg ttggcccagg cgttgatcga
    16381 tgtcggcggg tccggtgagt cggcgccgcg tctgtggctg gtcacggaag ctgccgtcgt
    16441 gatcggtgct gccgacaccg gtgcggtgat cgaccccgta cacgcgcagc tgtggggctt
    16501 cggccgtgtc cttgctctgg aacaccccga attgtggggc gggctgatcg acctgcccgc
    16561 tgtggcaggc gagcctggtt cgattaccga ccacgcgcat gccgacctac tggccacggt
    16621 cctggccacg atggtgcagg ctgctgcccg aggcgaggac caggtcgcgg tccggacgac
    16681 cggtacttac gtacccaggc tggtgcgttc aggcggcagt gcacactcgg gtgcgcggag
    16741 gtggcagccg cgcgacaccg tactggtcac cggcgggatg ggaccgctga ccgcccacat
    16801 cgtccgttgg ctggctgaca acggtgccga ccaggtagta ctcctgggag gtcagggagc
    16861 agacggcgag gccgaggcgc tgagggccga gttcgacggg cacacgacga agatcgaact
    16921 cgcggacgtg gacaccgagg acagcgacgc gctgcggtcc ttgctcgacc gcacgaccgg
    16981 cgaacacccg ctgcgcgcgg tcatccatgc gccgaccgtg gtcgagttcg cctcggtggc
    17041 cgagtcggac ctggtgcgat tcgcccgcac catcagcagc aagatcgccg gcgtcgagca
    17101 gctcgacgag gtgctgagcg gcatcgacac ggcgcacgac gtggtcttct tctcctccgt
    17161 cgcgggcgtc tggggaagcg cggggcagag cgcctacgcg gcgggcaacg ccttcctcga
    17221 cgccgtcgcc cagcaccgcc gtctgcgcgg actgcccggt acgtcggtgg cctggactcc
    17281 gtgggacgac gatcgatccc ttgcctccct cggtgactcg tacctcgacc gacgaggact
    17341 gcgagcactg tccatacccg gcgcgctcgc ctccctccag gaagtgctcg accaggacga
    17401 ggtccacgcc gtggtggcgg atgtcgactg ggagcggttc tacgccggct tcagtgccgt
    17461 ccggcgcact tccttcttcg acgacgtgca cgacgcccac cggccggccc tgtccacggc
    17521 tgcgaccaac gacggacagg cccgggacga ggacggcggt acggaactcg tacgacgtct
    17581 gcgtccgctg accgagacgg agcaacagcg agagctcgtg tcgctcgtcc agagtgaagt
    17641 cgctgccgtc ctaggccact cctccaccga cgcggtccag ccacagcgcg cgttccgaga
    17701 gatcgggttc gactcactga cagcggtcca gctccggaac cggcttacgg ccaccacggg
    17761 catgcgcctt ccgacaacgc tggtcttcga ctacccgacc accaacggac tcgccgagta
    17821 cctgcgctcc gaactgttcg gtgtgtccgg cgcaccagct gacctctccg tcgtccggaa
    17881 cgcggatgag gaggacgacc ccgtcgtcat cgtggggatg gcctgccggt tcccgggcgg
    17941 gatcgatacg ccggaagcct tctggaagct gctcgaagcg ggcggcgatg tcatctccga
    18001 acttccggcc aaccgcggct gggacatgga gcgactcctg aacccggacc ccgaggcgaa
    18061 gggcaccagc gccacacgct acggcggttt cctctacgac gccggggagt tcgacgccgc
    18121 cttcttcggt atctcgccgc gtgaggcgtt ggcgatggac ccgcagcaac ggctgctgct
    18181 ggaaaccgtc tgggagctca tcgagagcgc cggcgtggcg cccgactcgc tccaccggag
    18241 ccggaccggc acgttcatcg gcagcaacgg ccagttctac gcaccgctgc tgtggaactc
    18301 cggcggtgat ctggagggct accaaggcgt gggcaacgcc ggcagcgtca tgtccggccg
    18361 cgtcgcctac tccctcggtc ttgaggggcc tgcggtgacg gtggatacgg cgtgttcgtc
    18421 gtcgctggtg gcactgcacc tggcggtgca ggcgctgcgc cgtggcgagt gctcactcgc
    18481 catagccggc ggtgtgacgg tgatgtccac accggacagc ttcgttgagt tctcacggca
    18541 acagggcctt tccgaggacg gccgttgcaa ggcgttcgcg agcacagccg atggtttcgg
    18601 cctcgccgag ggcgtttcgg cgctgttggt ggagcggttg tcggatgcgc ggcggttggg
    18661 tcatcgggtg ttggcggtgg tgcgggggag tgcggtcaat caggatggtg cgtcgaatgg
    18721 gttgacggcg ccgaatggtc cgtcgcagca gcgggtgatt cgtgcggcgt tggctgacgc
    18781 gggtctggct cctgctgatg tggatgtggt ggaggcgcat ggtacgggga cgcggttggg
    18841 tgatccgatc gaggctcagg cgttgttggc gacgtatggg cagggtcgtg cgggtgggcg
    18901 tccggtggtg ttggggtcgg tgaagtcgaa catcgggcat acgcaggcgg cggctggcgt
    18961 ggctggtgtg atgaagatgg tgctggcgct ggagcggggt gtggtgccga agacgttgca
    19021 tgtggatgag ccgtcaccgc atgtggactg gtcggctggt gaggtggagt tggcggttga
    19081 ggcggtgccg tggtcgcggg gtgggcgggt gcggcgggct ggtgtgtcgt cgttcgggat
    19141 cagtggcacg aatgcgcatg tgattgtgga ggaggcgcct gcggagccgg agccggagcc
    19201 gggaactcgt gtggttgctg ctggtgatct ggtggtgccg tgggtggtgt ccgggcggga
    19261 tgcgggggcg ttgcgtgagc aggcggcccg gttggctgcg cacgtgtcga gcacgggtgc
    19321 gggtgtggtt gatgtggggt ggtcgttggt ggccacgagg tcggtgttcg agcaccgggc
    19381 ggtgatggtc ggcagtgaac tcgattccat ggcggagtcg ttggctggct tcgctgcggg
    19441 tggggttgtg ccgggggtgg tgtcgggtgt ggctccggct gagggtcgtc gtgtggtgtt
    19501 cgtctttcct ggtcagggtt cgcagtgggt ggggatggcg gctgggttgc tggatgcgtg
    19561 tccggtgttc gcggaggcgg tggcggagtg tgccgcggtg ctggatccgg tgacgggttg
    19621 gtcgctggtc gaggtgttgc gcggtggtgg tgaggctgtt cttgggcggg ttgatgtggt
    19681 gcagccggcg ttgtgggcgg tgatggtgtc actggcccgg acctggcggt attacggtgt
    19741 ggagcctgct gcggttgtgg ggcattcgca gggtgagatc gctgcggctt gtgtggctgg
    19801 ggggttgagt ctggccgatg gtgcgcgggt ggtggtgttg cggagccggg cgatcgcccg
    19861 gatcgctggt gggggcggca tggtctcggt cggtctttca gctgagcgtg tccgcaccat
    19921 gctcgacacc tacggtggcc gggtttcggt cgcggcggtc aatggcccgt cctcgaccgt
    19981 cgtgtccggt gacgtccagg ccctggatga gttgttggcc ggttgtgagc gggagggtgt
    20041 ccgggctcgt cgtgtcccgg tggactatgc ctcccactcc gcgcagatgg accagttacg
    20101 cgatgagctg ctggaagcgc tggcggacat cactccgcaa cattccagtg ttccgttctt
    20161 ctcgacggtg acggcggact ggctggacac gaccgctctg gatgcggggt actggttcac
    20221 gaatctgcgg gagacggtcc ggttccagga agccgtcgaa gggctcgtgg ctcaggggat
    20281 gggcgcgttc gtcgagtgca gcccgcaccc cgtcctcgtc cccggtatcg agcagaccct
    20341 cgacgccctc gaccagaacg ccgccgtact cggctccctg cggcgtgacg aaggcggcct
    20401 ggaccgactc ctcacatccc tcgcggaagc cttcgtccaa ggcgttcccg tcgactggac
    20461 ccacgccttc gaaggcatga ccccccgcac cgtcgacctg cccacctacc ccttccaacg
    20521 acagcactac tggcccaagc ccgcaccggc ccccggcgcg aacctgggcg acgtggcgtc
    20581 cgtgggcctc accgcggccg gccaccccct tctgggcgcg gtcgtggaga tgcccgactc
    20641 cgacgggttg gtgctcaccg ggcagatctc cctgcggacc catccctggc tcgccgacca
    20701 cgaggtgctc ggatcggtgc tcctgccggg caccgcgttc gtcgagcttg ccgtccaggc
    20761 cgccgaccgc gccggttacg acgtactgga cgagctgacg ctggaggcgc ccctcgtgct
    20821 ccccgacagg ggcggcatcc aggtgcgtct ggccctcggg ccgtccgagg cagacggacg
    20881 ccggtccctc cagctgcaca gcaggccgga ggaggctgcc gggttccacc gctggacgag
    20941 gcacgcgagt ggattcgtcg ttcccggcgg taccggggcg gcgcggccca ccgagccggc
    21001 cggcgtgtgg ccgcccgcag gtgccgagcc ggtcgctctc gcatcggacc ggtacgcccg
    21061 gctcgtcgag cgcggctaca cctacggccc ctccttccag gggctgcaca ccgcatggcg
    21121 ccacggggac gacgtgtacg cggaagtggc gctgccagaa ggaacaccgg ccgacggcta
    21181 cgccctgcat ccggccctgc tggacgcggc ggtccaggcc gtcggactcg gctcgttcgt
    21241 cgaggatccc ggccaggtgt acctgccgtt cctctggagc gacgtgacgc tgcacgcgac
    21301 cggggccacg tccctgcggg tgagggtttc accggccggt cccgacaccg ttgcgctggc
    21361 cctcgccgac ccggccgggg cgccggtggc cacggtgggc gccctccgtc tgcgtacgac
    21421 gtccgcggcg cagctcgccc gtgcgcgcgg gagcgcggaa cacgcgatgt tccgcgtgga
    21481 gtgggtggag gagggctcgg ccgcggaccg gtgccggggc ggcgcgggcg ggacgacgta
    21541 cgagggggaa cgcgccgccg aggccggggc cgccgctggt acctgggccg tactcggccc
    21601 ccgggtgccg gccgccgtcc ggacgatggg cgtggatgtc gtcaccgccc tcgacacgcc
    21661 ggaccacccc gcggacccgc agagcctcgc ggacctggcg gcgctcgggg acaccgttcc
    21721 cgacgtggtc gtcgtgacca gcctcctgag cctcgcctcc ggagcggatt cccccctagg
    21781 gaaccggccc cggccgaccg ccgccgagca ggacaccgcc gccacggtcg ccggcgtcca
    21841 cagcgcactc cacgcggccc tggacctggt gcaggcatgg ctggccgacg aacgccacac
    21901 cgcctcccgg ctggtgctcg tcacccggca cgcgatgacc gtcgccgagt ccgaccccga
    21961 gcctgacctg ctcctcgccc cggtgtgggg actcgtgcgg tccgcccagg ccgagaaccc
    22021 cggccgcttc gtgctcgccg acatcgacgg cgacgaggca tcctgggatg ctctgccccg
    22081 agccgtcgcc tcggccgcat cggaggtggc gatacgggcc ggcgccgtgt acgtaccgcg
    22141 gctggcccgc gccacggacg agggactggt cgtggccgac gaggctgcgg ggccctggcg
    22201 gctggacgtc acggaagcgg gcaccctggc gaacctcgcc ctggtgccgt gcccggacgc
    22261 ctcccgcccg ctgggccccg acgaggtacg gatcgccgtc cgtgccgccg gggtcaactt
    22321 ccgggacgtc ctcctggccc tgggcatgta cccggacgag gggctcatgg gcgcggaggc
    22381 ggcgggcgtc gtcaccgagg tcggcggggg cgtcacgacg ctcgcgccag gtgaccgggt
    22441 gatgggcctg gtgaccggtg gattcgggcc ggtggccgtg acgcaccacc ggatgctcgt
    22501 acggatgccg cgtggctggt ccttcgccga ggccgcgtcg gtgccggtgg cgttcctgac
    22561 cgcgtactac gccctgcacg acctggcagg cctgcgcggc ggcgagtcgg tgctggtgca
    22621 ctccgctgcg ggcggtgtcg gcatggcggc cgtgcagttg gcacggcact gggatgccga
    22681 ggtgttcggc accgcgagca agggcaagtg ggacgttctc gcggcgcagg gcctcgacga
    22741 ggagcacatc ggctcgtcca ggacgaccga gttcgagcag cgcttccgcg cgaccagtgg
    22801 tgggcgcggg atcgatgtcg tcctgaatgc cctctcgggt gacttcgtcg acgcctcggc
    22861 gcgtctcctg cgcgagggcg gccggttcgt cgagatgggc aagaccgaca tccgtaccga
    22921 cctcggcgtc gtcggggcgg acggcgtccc ggacatccgg tacgtcgcct tcgacctcgc
    22981 cgaggcgggt gccgagcgga tcgggcagat gctcgacgag atcatggcgc tcttcgacgc
    23041 cggtgtcctg cggttgccgc cgttgcgcgc ctggccggtg cggcgcgccc acgaggcact
    23101 gaggttcgtc agccaggcac gtcatgtggg caaggtcgtc ctcaccgtcc cggccgcgct
    23161 cgacgccgag ggaaccgtgc tgatcaccgg ggcgggcacg ctgggagccc tggtcgcccg
    23221 ccacctcgtc accgagcacg acgtccgccg gctgctgctg gtcagccgca gcggcgtcgc
    23281 ccccgacctg gcggccgaac tcggtgcgct gggcgccgag gtcacggtgg cggcctgcga
    23341 cgtcgccaac cgcaaggcgc tcaaggccct cctggaggac ataccgcccg agcatccggt
    23401 cacgggcatc gttcacacgg ccggcgtgct cgacgacggt gtggtgtccg ggctcacccc
    23461 tgaacgggtg gacaccgtcc tcaaacccaa ggtggacgcg gccctgaccc tggagtcagt
    23521 gatcggcgaa ctggacctcg acccggccct gttcgtgatc ttctcatcgg cagcgagcat
    23581 gctgggcggg cccggccagg gcagttacgc cgcggccaat cagttcctgg acaccctcgc
    23641 ccgacaccgg gcgcgccgcg ggctcacctc cgtgtcactc ggctgggggc tgtggcacga
    23701 ggccagcggt ctcaccggcg gcctggccga catcgaccgt gaccggatga gccgggcggg
    23761 gatcgcgccc atgccgaccg acgaggccct gcacctgttc gacagggcaa cggaactcgg
    23821 cgatccggta ctcctgccga tgcgcctgaa cgaggccgcg ctggaggacc gggccgcgga
    23881 cggaacactg ccgccgctgc tgagtggtct ggtccgggtg cggcacaggc cgtcggcgcg
    23941 ggcaggtacc gcgaccgccg cccccgccac cggccccgag gcgttcgccc gggagctggc
    24001 ggcggcaccg gacccacgtc gtgccctgcg cgacctcgtc cgcggccacg tcgccctggt
    24061 gctcggacac agtggccccg aggccatcga cgccgaacag gccttccggg acatcggttt
    24121 cgactccctg accgcagtcg aactcagaaa ccggctgaac gccgagaccg gcctccgctt
    24181 gcccggcacg ctcgtgttcg actaccccaa cccgagcgcg ctcgccgatc acctgctcga
    24241 actcctcgct cccgcgacac aacccaccgc agccccgctg ctcgccgaac tggaacgggt
    24301 ggaacaactc ctgtctgcgg ccgcgtcacc cggcggaccg gcatccgcgg tggacgagga
    24361 gacgcgcacg ctcatcgcca cacggctggc cacccttgcc tcgcagtgga cacacctccc
    24421 ggtcggttcg ccgggcaacg cggacaaccg cagcggcccc ggcgagtccg ggcaggccca
    24481 ggaatccgga gcaaccgggg agcacacggc ggcgtggacg tcggacgacg atctcttcgc
    24541 cttcctcgac aagcggttgg agacgtga
//